55 Is Nephron Number Reduction Sufficient to Explain the Fetal Programming of Hypertension
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چکیده
منابع مشابه
Transgenerational programming of fetal nephron deficits and sex-specific adult hypertension in rats.
A developmental insult that restricts growth in the first generation has the potential to program disease in subsequent generations. The aim of this study was to ascertain transgenerational growth and cardio-renal effects, via the maternal line, in a rat model of utero-placental insufficiency. Bilateral uterine vessel ligation or sham surgery (offspring termed first generation; F1 Restricted an...
متن کاملMaternal nutrition, low nephron number, and hypertension in later life: pathways of nutritional programming.
A large body of epidemiologic literature supports an inverse relation between birth weight and both systolic blood pressure and prevalence of hypertension, but mechanisms through which lower birth weight increases risk for hypertension are not established. This article advances the view that 1) permanently reduced nephron number is essential but not alone sufficient to mediate nutritionally ind...
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در دوره های آموزش ترجمه استادان بیشتر سعی دارند دانشجویان را با انواع متون آشنا سازند، درحالی که کمتر به خطاهای مکرر آنان در متن ترجمه شده می پردازند. اهمیت تحقیق حاضر مبنی بر ارتکاب مکرر خطاهای ترجمانی حتی بعد از گذراندن دوره های تخصصی ترجمه از سوی دانشجویان است. هدف از آن تاکید بر خطاهای رایج میان دانشجویان مترجمی و کاهش این خطاها با افزایش آگاهی و هوشیاری دانشجویان از بروز آنها است.از آنجا ک...
15 صفحه اولNephron number and renal risk in hypertension and diabetes.
It has been proposed that "nephron underdosing," i.e., a low number of nephrons at the time of birth, is linked to essential hypertension and a greater propensity to develop progressive loss of renal function after renal injury. This hypothesis was confirmed recently by examining the number of glomeruli in patients with essential hypertension. The mechanisms through which a low number of nephro...
متن کاملNephron number, hypertension, renal disease, and renal failure.
Wendy E. Hoy,* Michael D. Hughson, John F. Bertram, Rebecca Douglas-Denton, and Kerstin Amann *Centre for Chronic Disease, University of Queensland, Brisbane, Australia; University of Mississippi Medical Center, Jackson, Mississippi; Department of Anatomy and Cell Biology, School of Biomedical Sciences, Monash University, Victoria, Australia; and Department of Pathology, University of Erlangen-...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 2005
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-200508000-00084